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phenobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may well improve the metabolism of ifosfamide to its Energetic alkylating metabolites.This system is most likely from the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital